News Health/Medical Proteomic Risk Factors for Cancer: Insights from UK Biobank

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Proteomic Risk Factors for Cancer: Insights from UK Biobank

Researchers have made significant strides in understanding cancer risk factors by analyzing a vast array of plasma proteins. In a groundbreaking study, scientists investigated associations between 1463 circulating proteins and the incidence of 19 different cancers in participants from the UK Biobank, with an average follow-up period of 12 years.

Key Findings

From this comprehensive analysis, they identified 618 protein-cancer associations. Remarkably, 107 of these associations persisted for cases diagnosed more than seven years after blood draw. Additionally, 29 associations were supported by genetic analyses, emphasizing their potential role in cancer development.

Noteworthy Associations

Among the notable findings were:

  • CD74 and TNFRSF1B: Associated with non-Hodgkin lymphoma (NHL)
  • ADAM8: Linked to leukemia
  • SFTPA2: Implicated in lung cancer

These associations provide valuable insights into early cancer detection and prevention.

Proteins: Key Players in Carcinogenesis

Proteins play integral roles in biological processes, including those that lead to cancer. While previous studies identified specific cancer-related proteins, new multiplex proteomics methods allow simultaneous measurement of thousands of proteins across various cancer sites.

Genetic predictors of protein levels, known as cis-protein quantitative trait loci (cis-pQTL), offer complementary evidence. By leveraging inherited genetic variation, researchers gain insights into protein-cancer associations, even in prospective data with potential confounding factors.

These findings underscore the importance of proteomic research in unraveling cancer risk factors and advancing personalized medicine.

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