News Health/Medical Proteomic Risk Factors for Cancer: Insights from UK Biobank

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Proteomic Risk Factors for Cancer: Insights from UK Biobank

Researchers have made significant strides in understanding cancer risk factors, and a recent study sheds light on the role of circulating proteins. Using data from the UK Biobank, scientists investigated associations between 1463 plasma proteins and the incidence of 19 different cancers and 9 cancer subsites. Here are the key findings:

Protein-Cancer Associations

A total of 618 protein-cancer associations were identified. These associations included proteins that were detectable more than seven years before cancer diagnosis. Notably, 107 of these associations persisted for cases diagnosed long after blood draw.

Genetic Approaches

Two genetic approaches were used to explore emerging protein-cancer associations:

  • cis-pQTL: Genetic variants in a protein's cognate gene that influence protein levels directly.
  • Exome-wide protein genetic scores (exGS): Genetic predictors of protein levels.

Highlighted Associations

Four associations stood out:

  1. CD74 and TNFRSF1B with non-Hodgkin lymphoma (NHL)
  2. ADAM8 with leukemia
  3. SFTPA2 with lung cancer

These findings suggest that certain proteins play a possible role in cancer development and may serve as valuable markers for early detection and risk assessment.

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