News Health/Medical Managing CAR T-Cell Therapy Complications: Rethinking MRI and Lumbar Puncture
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Managing CAR T-Cell Therapy Complications: Rethinking MRI and Lumbar Puncture

March 19, 2024

By Copilot News


When it comes to treating patients with CAR T-cell therapy, medical guidelines have traditionally relied on rigid protocols based on early-phase studies. However, a recent study challenges the necessity of two diagnostic procedures: magnetic resonance imaging (MRI) and lumbar puncture (LP). Let's delve into the findings and implications.

The Neurological Complication

CAR T-cell therapy, while promising, can lead to immune effector cell-associated neurotoxicity syndrome (ICANS). Patients experiencing ICANS may present with a range of neurological symptoms, including confusion, tremors, seizures, and, in severe cases, brain swelling and comas.

The Diagnostic Dilemma

Traditionally, health care providers have turned to MRI, LP, and electroencephalogram (EEG) to diagnose and manage ICANS. However, these interventions are costly, invasive, and often fail to alter treatment decisions.

The Study

Researchers collected data from 190 patients treated with CAR T-cells. Among those who developed ICANS, 80% underwent at least one intervention, and 34% underwent all three (MRI, LP, and EEG).

EEG as a Game Changer

The study validated the use of EEG as a noninvasive alternative for managing neurotoxicity. Unlike MRI and LP, EEG provides valuable insights without subjecting patients to unnecessary discomfort.


As we rethink our approach to CAR T-cell therapy complications, it's time to consider alternatives to invasive diagnostic tests. EEG emerges as a promising tool, sparing patients unnecessary procedures while ensuring effective management.

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